Comparison of long‐term systemic and secretory antibody responses in children given live, attenuated, or inactivated influenza A vaccine
Identifieur interne : 002469 ( Main/Exploration ); précédent : 002468; suivant : 002470Comparison of long‐term systemic and secretory antibody responses in children given live, attenuated, or inactivated influenza A vaccine
Auteurs : Philip R. Johnson Jr. [États-Unis] ; Sandor Feldman ; Juliette M. Thompson ; Josephine D. Mahoney ; Peter F. WrightSource :
- Journal of Medical Virology [ 0146-6615 ] ; 1985-12.
English descriptors
- Teeft :
- American journal, Antibody, Antibody assays, Antibody response, Antibody responses, Antibody titer, Antibody titers, Assay, Attenuated, Attenuated influenza, Bovine serum albumin, Carbonate buffer, Chanock, Disease control, Early infancy, Elisa, Experimental immunology, Flow laboratories, Genes encoding, Human services, Immune responses, Immunology, Immunosorbent assay, Infection, Infectious diseases, Influenza, Influenza vaccine, Influenza vaccines, Influenza virus vaccine, Intramuscular, Intranasal, Intranasal vaccination, Jude research hospital, Kasel, Local production, More months, More years, Nasal, Nasal antibody, Nasal antibody responses, Nasal secretions, Nasal washings, National institute, Natural infection, Parenteral, Phelan, Present study, Primary immunization, Protective effect, Respiratory secretions, Respiratory syncytial virus, Responder, Secretory, Secretory antibody, Secretory antibody responses, Seronegative children, Serum antibody, Serum antibody response, Serum antibody responses, Single dose, Systemic, Systemic antibodies, Systemic immunity, Titer, Vaccination, Vaccine, Vaccine recipients, Vaccine responders, Vaccine virus, Vaccinee, Vanderbilt university, Whole virus vaccine, Young children.
Abstract
A comparison of inactivated intramuscular and live intranasal influenza A vaccines in young children undergoing primary immunization might be expected to show differences in serum and local mucosal antibody responses. To demonstrate such differences, serum and local respiratory tract antibody responses of young children vaccinated with intranasal live, attenuated, cold‐adapted (H3N2 or HINI), or intramuscular inactivated (H3N2) influenza A vaccines were examined for one year after vaccination. Antibody responses were measured by hemagglutination inhibition (HAI) and class‐specific enzyme‐linked immunosorbent assay (ELISA). One year after vaccination, live intranasal vaccinees had significantly less decay of serum HAI (p = 0.025) and IgG antibody (p = 0.01) directed against the influenza hemagglutinin and neuraminidase than did intramuscular inactivated vaccinees. Nasal secretory IgA developed almost exclusively in live vaccinees and persisted for up to one year. Persistent nasal secretory IgG was detected in both live and inactivated vacinees. Live vaccination not only stimulates a more durable serum antibody response, but also induces long‐lasting local respiratory tract IgA antibody that may play an important role in host protection.
Url:
DOI: 10.1002/jmv.1890170405
Affiliations:
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Mahoney</name></author><author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. 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Wright</name><affiliation><wicri:noCountry code="subField">Tennesse</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="325">325</biblScope><biblScope unit="page" to="335">335</biblScope><biblScope unit="page-count">11</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1985-12">1985-12</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>American journal</term><term>Antibody</term><term>Antibody assays</term><term>Antibody response</term><term>Antibody responses</term><term>Antibody titer</term><term>Antibody titers</term><term>Assay</term><term>Attenuated</term><term>Attenuated influenza</term><term>Bovine serum albumin</term><term>Carbonate buffer</term><term>Chanock</term><term>Disease control</term><term>Early infancy</term><term>Elisa</term><term>Experimental immunology</term><term>Flow laboratories</term><term>Genes encoding</term><term>Human services</term><term>Immune responses</term><term>Immunology</term><term>Immunosorbent assay</term><term>Infection</term><term>Infectious diseases</term><term>Influenza</term><term>Influenza vaccine</term><term>Influenza vaccines</term><term>Influenza virus vaccine</term><term>Intramuscular</term><term>Intranasal</term><term>Intranasal vaccination</term><term>Jude research hospital</term><term>Kasel</term><term>Local production</term><term>More months</term><term>More years</term><term>Nasal</term><term>Nasal antibody</term><term>Nasal antibody responses</term><term>Nasal secretions</term><term>Nasal washings</term><term>National institute</term><term>Natural infection</term><term>Parenteral</term><term>Phelan</term><term>Present study</term><term>Primary immunization</term><term>Protective effect</term><term>Respiratory secretions</term><term>Respiratory syncytial virus</term><term>Responder</term><term>Secretory</term><term>Secretory antibody</term><term>Secretory antibody responses</term><term>Seronegative children</term><term>Serum antibody</term><term>Serum antibody response</term><term>Serum antibody responses</term><term>Single dose</term><term>Systemic</term><term>Systemic antibodies</term><term>Systemic immunity</term><term>Titer</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine recipients</term><term>Vaccine responders</term><term>Vaccine virus</term><term>Vaccinee</term><term>Vanderbilt university</term><term>Whole virus vaccine</term><term>Young children</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A comparison of inactivated intramuscular and live intranasal influenza A vaccines in young children undergoing primary immunization might be expected to show differences in serum and local mucosal antibody responses. To demonstrate such differences, serum and local respiratory tract antibody responses of young children vaccinated with intranasal live, attenuated, cold‐adapted (H3N2 or HINI), or intramuscular inactivated (H3N2) influenza A vaccines were examined for one year after vaccination. Antibody responses were measured by hemagglutination inhibition (HAI) and class‐specific enzyme‐linked immunosorbent assay (ELISA). One year after vaccination, live intranasal vaccinees had significantly less decay of serum HAI (p = 0.025) and IgG antibody (p = 0.01) directed against the influenza hemagglutinin and neuraminidase than did intramuscular inactivated vaccinees. Nasal secretory IgA developed almost exclusively in live vaccinees and persisted for up to one year. Persistent nasal secretory IgG was detected in both live and inactivated vacinees. Live vaccination not only stimulates a more durable serum antibody response, but also induces long‐lasting local respiratory tract IgA antibody that may play an important role in host protection.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><noCountry><name sortKey="Feldman, Sandor" sort="Feldman, Sandor" uniqKey="Feldman S" first="Sandor" last="Feldman">Sandor Feldman</name><name sortKey="Mahoney, Josephine D" sort="Mahoney, Josephine D" uniqKey="Mahoney J" first="Josephine D." last="Mahoney">Josephine D. Mahoney</name><name sortKey="Thompson, Juliette M" sort="Thompson, Juliette M" uniqKey="Thompson J" first="Juliette M." last="Thompson">Juliette M. Thompson</name><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></noCountry><country name="États-Unis"><region name="Tennessee"><name sortKey="Johnson Jr, Philip R" sort="Johnson Jr, Philip R" uniqKey="Johnson Jr P" first="Philip R." last="Johnson Jr.">Philip R. Johnson Jr.</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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